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pentobarbital will decrease the level or influence of nilotinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will increase effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Warning/Check. Coadministration of ifosfamide with CYP2B6 inducers may raise metabolism of ifosfamide to it